Related Experiment Video
Updated: Mar 5, 2026

06:33
Production of Human CRISPR-Engineered CAR-T Cells
Published on: March 15, 2021
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Abstract:
Using CRISPR/Cas9 technology, researchers have devised a method to deliver a CAR gene to a specific locus, TRAC, in T cells. This targeted approach yielded therapeutic cells that were more potent even at low doses; in a mouse model of acute lymphoblastic leukemia, they outperformed CAR T cells created with a randomly integrating retroviral vector.
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