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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

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Glutathione-S-transferase-pi (GST-pi) expression in renal cell carcinoma

Christina Kaprilian1, Maria Horti1, Kosmas Kandilaris1

  • 1Department of Pathology, Sismanoglio General Hospital, Sismanogliou 1, Marousi 15126, Athens, Greece; Department of Clinical Chemistry Sismanoglio General Hospital of Attica; 2nd Department of Urology Athens Medical School, Sismanoglio Hospital, Sismanogliou 1, Marousi 15126, Athens, Greece.

Journal of Kidney Cancer and VHL
|March 23, 2017
PubMed

Insights

Glutathione-S-transferase-pi (GST-pi) is highly expressed in most kidney tumors, but it does not appear to predict treatment outcomes or survival in renal cell carcinoma patients. Further research is needed to clarify its role in drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Multidrug resistance (MDR) is a significant challenge in cancer therapy, leading to poor treatment outcomes.
  • Glutathione-S-transferase-pi (GST-pi), a known MDR factor, has a controversial role in kidney tumors.
  • Understanding GST-pi expression in renal cell carcinoma (RCC) is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the expression levels of GST-pi in various subtypes of renal cell carcinoma.
  • To determine the clinical relevance and prognostic significance of GST-pi expression in RCC.
  • To explore the potential role of GST-pi in the context of multidrug resistance in kidney cancer.

Main Methods:

  • Immunohistochemistry was employed to analyze GST-pi expression in 60 RCC tissue samples.
  • Samples were compared with matched normal kidney tissue.
  • Expression levels were correlated with tumor grade and patient survival data.

Main Results:

  • Significantly elevated GST-pi expression was detected in 87% of clear cell carcinoma and 50% of papillary RCC subtypes.
  • GST-pi expression levels did not show a significant correlation with tumor grade.
  • No correlation was found between GST-pi expression and patient survival.

Conclusions:

  • GST-pi is frequently overexpressed in common subtypes of renal cell carcinoma.
  • Current findings suggest GST-pi is unlikely to serve as a prognostic biomarker for RCC.
  • Further large-scale studies are necessary to elucidate the role of GST-pi in intrinsic or acquired resistance to cancer therapies.

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