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Related Experiment Video

Updated: Mar 5, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

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Total knee arthroplasty in multiple sclerosis.

Kaitlyn E Hughes1, Darren Nickel2, Tanner Gurney-Dunlop3

  • 1University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Arthroplasty Today
|March 23, 2017
PubMed
Summary
This summary is machine-generated.

Total knee arthroplasty in multiple sclerosis (MS) patients can be complicated by spasticity. Careful preoperative, intraoperative, and postoperative planning is crucial for improving outcomes in MS patients undergoing knee surgery.

Keywords:
ComorbiditiesDisability ProgressionMultiple sclerosisSpasticityTotal knee arthroplasty

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Area of Science:

  • Orthopedic Surgery
  • Neurology
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) can cause spasticity and contractures, complicating orthopedic procedures.
  • Previous case reports highlight adverse outcomes of total knee arthroplasty (TKA) in MS patients due to severe spasticity.

Purpose of the Study:

  • To report a case of TKA complicated by spasticity and contractures in an MS patient.
  • To discuss critical considerations for MS patients undergoing TKA to improve functional outcomes.
  • To emphasize the need for further research on TKA timing and patient selection in MS.

Main Methods:

  • Case report presentation.
  • Review of literature on TKA in MS patients.
  • Discussion of preoperative, intraoperative, and postoperative management strategies.

Main Results:

  • The case highlights potential complications of TKA in MS patients, specifically related to spasticity and contractures.
  • Identified key factors influencing TKA outcomes in MS patients.

Conclusions:

  • Optimized perioperative management may improve functional outcomes for MS patients undergoing TKA.
  • Further prospective research is essential to guide TKA timing, patient selection, and complication mitigation in MS.