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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Transdermal hormone replacement therapy with nanostructured medicines.

Fatemeh Abdi1, Tayebeh Darooneh, Maryam Ghorbani

  • 1Student Research Committee, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. fatemeh.abdi87@yahoo.com.

Ginekologia Polska
|March 23, 2017
PubMed
Summary

Nanostructured hormone therapy effectively alleviates menopausal symptoms, reducing their frequency and severity. This approach offers a safe and effective treatment for women experiencing perimenopause and postmenopause.

Keywords:
hormone therapymenopausenanostructured medicine

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Area of Science:

  • Reproductive Endocrinology
  • Nanomedicine
  • Women's Health

Background:

  • Hormonal fluctuations during menopause cause diverse perimenopausal and postmenopausal symptoms.
  • Effective management strategies are crucial for improving the quality of life for menopausal women.

Purpose of the Study:

  • To review the application of nanostructured hormone therapy in treating menopausal symptoms.
  • To evaluate the safety and efficacy of nanomedicine in postmenopausal women's health.

Main Methods:

  • Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
  • Searched major databases including Excerpta Medica, PubMed, Web of Science, and Google Scholar.
  • Extracted and analyzed data from seven eligible studies out of 51 initial papers.

Main Results:

  • Nanostructured hormone therapy is confirmed as a safe and effective treatment for menopausal symptoms.
  • Studies indicate a significant decrease in the daily frequency and severity of menopausal symptoms with this therapy.
  • Transdermal nanoformulations show promise in relieving climacteric symptoms.

Conclusions:

  • Nanostructured hormone therapy provides a safe and effective means to alleviate menopausal symptoms.
  • Transdermal nanoformulations can relieve climacteric symptoms and prevent other postmenopausal issues.
  • This therapeutic approach contributes to maintaining postmenopausal women's health.