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Regulation of feeding behaviour in monosodium glutamate (MSG) treated mice
V Ma1, A Ma, D P Cameron
1Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Abstract:
Regulation of food intake was studied in mice treated neonatally with MSG. A diurnal pattern of food intake with a significantly greater nocturnal intake was observed. In response to restricted food availability (4 hours/day). MSG mice increased intake progressively although less efficiently than control mice. The opioid kappa receptor agonist ketocyclazocine enhanced food intake. It is concluded that in MSG treated mice opioid kappa receptor mechanisms involved with regulation of food intake are basically intact.
Insights
Neonatal monosodium glutamate (MSG) treatment in mice affects food intake patterns. However, opioid kappa receptor mechanisms regulating appetite remain functional in MSG-treated mice.
Area of Science:
- Neuroscience
- Endocrinology
- Behavioral Science
Background:
- Monosodium glutamate (MSG) is a common food additive.
- Neonatal exposure to MSG can alter neurodevelopment and physiological functions.
- Understanding the long-term effects of MSG on food intake regulation is crucial.
Purpose of the Study:
- To investigate the impact of neonatal MSG treatment on the regulation of food intake in mice.
- To assess the role of opioid kappa receptors in the feeding behavior of MSG-treated mice.
Main Methods:
- Mice were treated neonatally with MSG.
- Food intake patterns (diurnal and nocturnal) were monitored.
- Responses to restricted food availability were evaluated.
- The effect of a kappa opioid receptor agonist (ketocyclazocine) on food intake was assessed.
Main Results:
- MSG-treated mice exhibited a diurnal feeding pattern with greater nocturnal intake.
- While MSG mice increased food intake during food restriction, it was less efficient than controls.
- Ketocyclazocine administration enhanced food intake in MSG-treated mice.
Conclusions:
- Neonatal MSG treatment alters diurnal food intake patterns and reduces feeding efficiency under restriction.
- Opioid kappa receptor pathways involved in food intake regulation are fundamentally intact in MSG-treated mice.