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CTLA-4 gene polymorphisms associate with efficacy of postoperative radioiodine-131 for differentiated thyroid
De-Feng Chang1, Xiao-Hong Chen1, Jing Huang2
1The 2nd Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150030, China.
Aim:
To investigate the association of CTLA-4 polymorphisms with efficacy of postoperative radioiodine-131 (I-131) treatment for differentiated thyroid carcinoma (DTC).
Methods:
A total of 324 DTC patients and 350 healthy individuals were enrolled in our study. Patients received I-131 remnant ablation following surgical resection. Based on the treatment efficacy, patients were divided into the effective (n = 183) and ineffective groups (n = 141). CTLA-4 polymorphisms (+49A>G, CT60A>G and -318C>T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism.
Results:
AG + AA genotype distribution and A allele frequency of +49A>G and CT60A>G polymorphisms were higher in the effective group than the ineffective group.
Conclusion:
+49A>G and CT60A>G polymorphisms were associated with the efficacy of postoperative I-131 treatment for DTC; and they might be bioindicators related to the prognosis of I-131 treatment.
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