Related Experiment Video

Updated: Mar 5, 2026

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

15.7K

Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status

Héctor Rodríguez-Angulo1, Juan Marques2, Ivan Mendoza2

  • 1Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. hrodrigu@ivic.gob.ve.

BMC Infectious Diseases
|March 23, 2017
PubMed

Insights

This study reveals that elevated Interleukin-2 (IL-2) levels in Chagas disease patients may indicate a high risk of sudden death and serve as a marker for treatment effectiveness. Amiodarone shows potential as an anti-inflammatory coadjuvant therapy.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Cardiology

Background:

  • Chagas disease, caused by Trypanosoma cruzi, leads to heart failure and sudden death.
  • Predicting disease progression and treatment response in Chagas disease is complex.
  • Understanding the immune profile of patients is crucial for effective management.

Purpose of the Study:

  • To analyze the Th1/Th17 and Th2 serum cytokine profiles in Venezuelan Chagas disease patients.
  • To stratify patients based on amiodarone treatment, hypertension, and arrhythmias.
  • To identify immune markers associated with disease risk and treatment efficacy.

Main Methods:

  • Cytokine levels (IL-6, IL-2, TNF, IL-17, IFN-γ, IL-4, IL-10) were measured using Multiplexed Bead-Based Immunoassays in 38 patients.
  • Statistical analysis included ANOVA to compare groups.
  • Linear Discriminant Analysis (LDA) assessed cytokine discriminatory power.

Main Results:

  • Significantly higher cytokine levels were observed in untreated patients at high risk of sudden death.
  • IL-2, IFN-γ, and IL-10 were identified as key discriminators between high-risk/untreated and low-risk/treated groups.
  • Elevated IL-2 levels correlated with high-risk of sudden death.

Conclusions:

  • High IL-2 levels may identify patients at high risk of sudden death and serve as a treatment efficacy marker.
  • Amiodarone demonstrated an anti-inflammatory and immunomodulatory effect in Chagas disease.
  • Amiodarone could be a potential coadjuvant therapy for chronic Chagas disease.
Abstract

More Related Videos

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

3.2K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.8K

Related Concept Videos

Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
705
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
392
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
730
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
688
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
814
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
351