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Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes
Vanessa Bironneau1, François Goupil2, Pierre Henri Ducluzeau3
1Université Bretagne Loire, INSERM UMR 1063, Angers, France.
Cardiovascular Diabetology
|March 23, 2017
Summary
Obstructive sleep apnea (OSA) is common in type 2 diabetes (T2D) patients. This study found moderate to severe OSA does not impact micro-vascular endothelial function, despite associations with higher blood pressure and lower quality of life.
Area of Science:
- Cardiology
- Endocrinology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are linked to endothelial dysfunction, a key predictor of cardiovascular events.
- The prevalence of OSA in T2D patients is high, yet the effect of OSA severity on endothelial function remains unclear.
Purpose of the Study:
- To investigate the association between increasing obstructive sleep apnea severity and endothelial function in patients with type 2 diabetes.
Main Methods:
- A cross-sectional study involving 140 T2D patients without overt cardiovascular disease.
- Polysomnography was used to assess OSA severity (Apnea-Hypopnea Index: AHI).
- Endothelial function was measured using the reactive hyperemia index (RHI).
Main Results:
- Moderate (21.4%) and severe (47.6%) OSA were common in the T2D cohort.
- Increasing OSA severity did not correlate with a significant decrease in RHI (endothelial function).
- Despite no impact on RHI, severe OSA was linked to higher systolic blood pressure, lower adiponectin, higher sP-selectin, and reduced quality of life.
Conclusions:
- Moderate to severe obstructive sleep apnea is highly prevalent in type 2 diabetes patients.
- OSA severity does not appear to impact digital micro-vascular endothelial function in this population.
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