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Updated: Mar 5, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Published on: December 9, 2015

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Modeling multi-mutation and drug resistance: analysis of some case studies

Mitra Shojania Feizabadi1

  • 1Physics Department, Seton Hall University, 400 South Orange Ave, South Orange, NJ, 07079, USA. shojanmi@shu.edu.

Theoretical Biology & Medical Modelling
|March 23, 2017
PubMed
Summary

This study models cancer drug resistance, including intrinsic and drug-induced types. Mathematical simulations show that therapies effective against intrinsic resistance may fail or harm patients if the drug itself induces resistance.

Keywords:
Cancer modelingChemotherapyConjoint cell growthDrug resistanceMutation

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