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Related Experiment Videos

F/M ratios in polyneuropathy and spastic hyperreflexia.

M A Fisher1

  • 1Department of Neurology, Michael Reese Hospital, University of Chicago Pritzker School of Medicine, IL 60616.

Muscle & Nerve
|March 1, 1988
PubMed
Summary

F-wave to M-response amplitude ratios are elevated in polyneuropathies and spastic hyperreflexia, indicating increased central excitability or peripheral nerve injury. M-amplitudes decrease in patients with central lesions.

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Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • The F-wave to M-response amplitude ratio (mF AMP/M) is a neurophysiological parameter.
  • Understanding its alterations in neurological conditions is crucial for diagnosis.

Purpose of the Study:

  • To investigate the diagnostic utility of mF AMP/M ratios in patients with polyneuropathies and spastic hyperreflexia.
  • To compare these ratios with age-matched healthy controls.

Main Methods:

  • Measured mean F-wave amplitude (mF AMP) and maximum evoked motor response amplitude (M) in abductor pollicis brevis and calf muscles.
  • Calculated mF AMP/M ratios and compared between patient groups and controls.

Main Results:

  • mF AMP/M ratios were significantly increased in all patient groups compared to controls.
  • M amplitudes were significantly decreased in patients with peripheral or central lesions.
  • Increased mF AMP ratios in neuropathies correlated with disease duration.

Conclusions:

  • Elevated mF AMP/M ratios indicate increased central excitability or peripheral neuropathies.
  • Decreased M amplitudes are associated with central lesions.
  • The findings suggest a common physiological response to peripheral and central injury.

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