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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Micelles01:30

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Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Related Experiment Video

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Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles
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Hybrid Core-Shell (HyCoS) Nanoparticles produced by Complex Coacervation for Multimodal Applications.

D Vecchione1,2, A M Grimaldi3, E Forte3

  • 1Istituto Italiano di Tecnologia, Center for Advanced Biomaterials for Health Care IIT@CRIB, Largo Barsanti e Matteucci 53, 80125, Naples, Italy.

Scientific Reports
|March 23, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed biocompatible core-shell nanoparticles (HyCoS) for multimodal imaging. These stable nanostructures enhance MRI contrast agents and enable simultaneous optical imaging, offering radiation-free diagnostic potential.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Medical Imaging

Background:

  • Multimodal imaging probes combine diagnostic information from different modalities.
  • Nanoparticles (NPs) can encapsulate multiple imaging tracers for simultaneous diagnostic techniques.
  • Existing methods for nanoparticle synthesis may lack stability or efficiency.

Purpose of the Study:

  • To develop novel, biocompatible core-shell polymeric nanoparticles (HyCoS) for multimodal imaging applications.
  • To improve the stability and performance of nanoparticles for simultaneous MRI and optical imaging.
  • To explore the potential of HyCoS for triggered drug release.

Main Methods:

  • Utilized a complex coacervation process with controlled reaction temperature to synthesize HyCoS nanoparticles.
  • Developed a double-crosslinked system to enhance nanostructure stability with Gd-DTPA (MRI contrast agent).
  • Loaded HyCoS with dyes (ATTO 633) or conjugated with FITC for optical imaging capabilities.

Main Results:

  • Achieved a six-fold increase in relaxometric properties of Gd-DTPA through controlled crosslinking.
  • Demonstrated stable core-shell nanoparticles suitable for both MRI and optical imaging.
  • Showcased radiation-free detection capabilities for in vivo applications.
  • Reported preliminary data on pH-triggered drug release.

Conclusions:

  • HyCoS nanoparticles offer a stable and versatile platform for multimodal imaging.
  • The developed nanoparticles enhance MRI contrast and enable sensitive optical imaging.
  • HyCoS holds promise for advanced, radiation-free diagnostic tools and targeted drug delivery.