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Thyroid hormone profile in patients with chronic kidney disease: a single centre study
Journal of Nepal Health Research Council
|March 23, 2017
Summary
Thyroid hormone levels, including free triiodothyronine (fT3) and free thyroxine (fT4), are frequently altered in patients with chronic kidney disease (CKD). Most commonly, CKD patients exhibit low fT3 and fT4 with normal thyroid stimulating hormone (TSH).
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Chronic kidney disease (CKD) is a significant global health issue.
- CKD is associated with disruptions in thyroid hormone metabolism.
- Understanding these alterations is crucial for patient management.
Purpose of the Study:
- To investigate the thyroid hormone profile in patients with varying stages of CKD.
- To identify common thyroid function abnormalities in CKD.
- To correlate thyroid status with CKD progression and risk factors.
Main Methods:
- A cross-sectional study involving 103 CKD patients was conducted.
- Serum levels of creatinine, free triiodothyronine (fT3), free thyroxine (fT4), and thyroid stimulating hormone (TSH) were measured.
- Exclusion criteria included pre-existing thyroid conditions, relevant medications, and pregnancy.
Main Results:
- A significant proportion of CKD patients displayed altered thyroid hormone levels.
- Low fT3 (33.98%) and low fT4 (18.44%) with normal TSH were the most frequent findings.
- Elevated TSH with normal fT3 and fT4 was observed in 5.82% of patients.
- Creatinine, fT3, and fT4 levels varied significantly across different CKD stages.
Conclusions:
- Thyroid hormone profiles are demonstrably altered in CKD patients, particularly in stage 5.
- The predominant thyroid dysfunction observed was low fT3 and low fT4 with normal TSH.
- These findings highlight the importance of monitoring thyroid function in CKD management.
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