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Updated: Mar 5, 2026
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells
Chye Sheng Gan1,2, Pei Jean Lim3, Muhammad Fazril Mohamad Razif1
1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Introduction::
Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with DV, particularly DV serotype 2 (DV2).
Methods::
HepG2 cells were grown in various culture milieu. Total cellular RNA and proteins were extracted and quantified.
Results::
Results demonstrated sequestration of immunoproteasome subunits LMP2 and LMP7 in DV2-infected cells.
Conclusions::
This study provides insights into the mechanisms underlying immune evasion by DV.
