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Ganciclovir hepatotoxicity.

B F Shea1, S Hoffman, G P Sesin

  • 1Northeastern University College of Pharmacy and Allied Health Professions, Boston, Massachusetts.

Pharmacotherapy
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

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Ganciclovir, used for cytomegalovirus retinitis in an AIDS patient, caused liver damage. Liver function tests improved upon drug withdrawal, indicating ganciclovir as the likely cause of toxicity.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Cytomegalovirus (CMV) retinitis is a common opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS).
  • Ganciclovir is a standard antiviral medication used to treat CMV infections.

Observation:

  • A patient with AIDS and abnormal baseline liver function tests developed significant elevations in transaminases and alkaline phosphatase after initiating ganciclovir treatment.
  • These liver function abnormalities recurred upon drug rechallenge and resolved after drug discontinuation.

Findings:

  • The observed hepatic function abnormalities were acute, self-limited, and temporally associated with ganciclovir administration.
  • No other confounding toxic or infectious agents were identified as the cause of the liver injury.

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Implications:

  • Ganciclovir may pose a risk of drug-induced liver injury (DILI) in immunocompromised patients, particularly those with pre-existing liver dysfunction.
  • Close monitoring of liver function is crucial in patients receiving ganciclovir, especially those with AIDS.
  • This case highlights the importance of considering medication toxicity in the differential diagnosis of abnormal liver function tests in patients with complex medical conditions.