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Related Experiment Videos

Psychological stress increases pituitary cyclic AMP.

B N Bunnell1, J L Meyerhoff, G J Kant

  • 1Department of Medical Neurosciences, Walter Reed Army Medical Center, Washington, DC 20307.

Pharmacology, Biochemistry, and Behavior
|January 1, 1988
PubMed
Summary

Psychological stress in rats increases pituitary cyclic AMP, corticosterone, and prolactin. These neuroendocrine responses mirror those caused by physical stressors, suggesting a broad stress impact.

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Area of Science:

  • Neuroendocrinology
  • Stress Physiology
  • Behavioral Neuroscience

Background:

  • Physical stressors elevate pituitary cyclic AMP in rats.
  • Understanding stressor generality is crucial for stress research.

Purpose of the Study:

  • To investigate if psychological stressors elicit similar neuroendocrine responses as physical stressors.
  • To extend findings on pituitary cyclic AMP to a psychological stress paradigm.

Main Methods:

  • Rats were exposed to a psychological stressor (re-exposure to a context of prior footshock).
  • Pituitary cyclic AMP, plasma corticosterone, and prolactin levels were measured.
  • Compared responses to a physical stressor group.

Main Results:

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  • Psychological stress significantly increased pituitary cyclic AMP.
  • Plasma corticosterone and prolactin levels were also elevated in the psychological stress group.
  • These hormonal changes were comparable to those observed with physical stressors.

Conclusions:

  • Psychological stressors can induce significant neuroendocrine changes in rats.
  • The neuroendocrine system's response to stress may be generalized, irrespective of stressor type.
  • Further research is needed to determine if these effects result from associative conditioning or neurobiological sensitization.