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Versatile modes of cellular regulation via cyclic dinucleotides
Petya Violinova Krasteva1,2, Holger Sondermann3
1Unité G5 Biologie Structurale de la Sécrétion Bactérienne, UMR 3528 - CNRS, Institut Pasteur, Paris, France.
Nature Chemical Biology
|March 23, 2017
Summary
Cyclic dinucleotides (CDNs) like c-di-GMP are vital signaling molecules across life. This review explores recent discoveries on their diverse roles and mechanisms, particularly through structure-function analyses.
Area of Science:
- Molecular Biology
- Biochemistry
- Microbiology
Background:
- Cyclic dinucleotides (CDNs) are crucial second messengers found in all kingdoms of life.
- The CDN family includes c-di-GMP, c-di-AMP, and mixed cGAMP compounds.
- Numerous proteins regulate CDN production, turnover, and signal transduction.
Purpose of the Study:
- To review recent discoveries and emerging themes in CDN signaling.
- To highlight the ubiquity and versatility of CDNs at transcriptional and post-translational levels.
- To emphasize insights gained from mechanistic structure-function analyses.
Main Methods:
- Literature review focusing on recent advancements in CDN research.
- Analysis of structure-function relationships in CDN-binding proteins.
- Synthesis of findings on CDN roles in prokaryotic and eukaryotic systems.
Main Results:
- CDNs mediate diverse physiological responses, including prokaryotic adaptation and eukaryotic immunity.
- Recent studies reveal novel CDN functions and regulatory mechanisms.
- Structure-function studies provide mechanistic understanding of CDN signaling pathways.
Conclusions:
- Cyclic dinucleotides are fundamental to cellular signaling with broad physiological impacts.
- Continued research, especially structure-function analyses, is key to fully understanding CDN versatility.
- CDNs represent a conserved and adaptable signaling system with implications for health and disease.
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