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Updated: Mar 5, 2026

Frailty Assessment in an Aging Mouse Model

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

A Clinically Relevant Frailty Index for Aging Rats.

Marshall G Miller¹, Nopporn Thangthaeng¹, Barbara Shukitt-Hale¹

¹USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|March 23, 2017

Summary

This study developed a frailty index for aging Fischer (F344) rats, identifying frail animals. Frail rats showed significantly higher mortality risk, indicating the index

Keywords:

Animal model Biology of aging Motor activity

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Area of Science:

Gerontology
Animal Models
Biomedical Research

Background:

Frailty is a common aging syndrome linked to poor health outcomes.
Existing frailty indices need adaptation for preclinical research models.
Fischer (F344) rats are a widely used model for aging studies.

Purpose of the Study:

To adapt and validate frailty indices for aged Fischer (F344) rats.
To assess the predictive value of rat frailty for survival outcomes.

Main Methods:

Male Fischer (F344) rats (17 months old) underwent behavioral testing.
Tests included forelimb wire suspension (strength), rotarod (speed), open field (activity), and inclined screen (endurance).
Frailty was defined by poor performance in 2 (mildly frail) or 3-4 (frail) tasks.

Main Results:

17.29% of rats were classified as mildly frail, and 2.26% as frail.
Mildly frail rats had a 3.8-fold increased mortality risk over 100 days.
Frail rats exhibited a 27.5-fold increased mortality risk over 100 days.

Conclusions:

The developed frailty index effectively identifies frail aged Fischer (F344) rats.
This index predicts increased mortality risk in this aging rat model.
The findings support the use of this tool for preclinical frailty research.