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Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†.

Jasmin Hasmik Shahinian1, Bettina Mayer2, Stefan Tholen2

  • 1Deparment of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|March 23, 2017
PubMed
Summary
This summary is machine-generated.

Left ventricular assist device (LVAD) therapy significantly alters the heart

Keywords:
Left ventricular assist deviceMatrisomeMechanical unloadingReverse remodelling

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Area of Science:

  • Cardiovascular Research
  • Proteomics
  • Biochemistry

Background:

  • Mechanical unloading via left ventricular assist device (LVAD) is a critical therapy for heart failure.
  • Understanding the myocardial proteome's response to LVAD is essential for optimizing treatment.

Purpose of the Study:

  • To investigate the impact of LVAD therapy on the myocardial proteome in patients with non-ischaemic dilated cardiomyopathy.
  • To identify protein markers associated with LVAD support.

Main Methods:

  • Quantitative proteomics was employed on patient-matched myocardial tissue samples collected pre- and post-LVAD implantation.
  • Histological analysis assessed collagen deposition and immune cell infiltration.

Main Results:

  • LVAD therapy led to significant changes in the myocardial proteome, including decreased matricellular proteins and complement system components.
  • Increased levels of proteins involved in innate immunity and metabolic pathways were observed post-LVAD.
  • Histology showed no significant changes in collagen or immune infiltration, but proteomic data revealed inter-patient heterogeneity and altered proteolytic processing.

Conclusions:

  • LVAD therapy profoundly impacts the left ventricular myocardial proteome.
  • Alpha-1-antichymotrypsin and matricellular proteins are emerging as key protein markers of LVAD therapy.
  • Further research into proteomic changes can refine LVAD treatment strategies.