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Related Experiment Videos

The elastin receptor: a galactoside-binding protein.

A Hinek1, D S Wrenn, R P Mecham

  • 1Department of Cell Biology and Physiology, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110.

Science (New York, N.Y.)
|March 25, 1988
PubMed
Summary
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The elastin receptor

Area of Science:

  • Biochemistry
  • Cell Biology
  • Extracellular Matrix Research

Background:

  • The elastin receptor complex plays a role in cellular processes.
  • Its interaction with elastin is crucial for extracellular matrix formation.

Purpose of the Study:

  • To investigate the role of the elastin receptor complex in elastic fiber formation.
  • To identify the binding properties of the elastin receptor's 67 kDa component.

Main Methods:

  • Affinity chromatography using beta-galactoside columns.
  • Elution studies with lactose.
  • Cell surface protein release assays.
  • Inhibition studies of elastin binding and fiber formation.

Main Results:

Related Experiment Videos

  • A 67 kDa protein component of the elastin receptor binds to beta-galactoside residues.
  • Lactose elutes this component and inhibits its association with elastin.
  • Lactose also blocks elastic fiber formation in chondroblasts.

Conclusions:

  • The galactoside-binding property of the elastin receptor's 67 kDa component is implicated in elastic fiber formation.
  • Lactose interference suggests a mechanism for regulating elastin-related processes.