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Primary cutaneous marginal-zone lymphoma.

Joshua Farhadian1, Vtaly Terushkin, Shane A Meehan

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Summary
This summary is machine-generated.

Primary cutaneous marginal-zone lymphoma (PCMZL) is a common skin cancer with a high survival rate. This case highlights a rare presentation of PCMZL in a young woman.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Primary cutaneous B cell lymphomas (PCBCL) are the second most common cutaneous lymphomas.
  • Key subtypes include primary cutaneous marginal-zone lymphoma (PCMZL), primary cutaneous follicle-center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type.
  • PCMZL is characterized by an indolent course and a five-year survival rate nearing 99%.

Purpose of the Study:

  • To report a case of primary cutaneous marginal-zone lymphoma (PCMZL) in a young Hispanic woman.
  • To describe an unusual presentation of PCMZL on the face.

Main Methods:

  • Case report of a 33-year-old Hispanic woman.
  • Clinical presentation: firm, pruritic, pink papules on the forehead and cheeks.
  • Diagnosis of PCMZL confirmed.

Main Results:

  • The patient presented with facial papules, an atypical location for PCMZL.
  • PCMZL lesions commonly appear as erythematous-to-violaceous papules, plaques, or nodules, typically on the trunk or arms.
  • Approximately 50% of patients have solitary skin lesions.

Conclusions:

  • Primary cutaneous marginal-zone lymphoma (PCMZL) can present atypically in terms of patient demographics and lesion location.
  • Early diagnosis and appropriate treatment are crucial for managing PCBCL.
  • This case underscores the importance of considering PCMZL in the differential diagnosis of facial papular lesions.