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Eosinophilic dermatosis of hematologic malignancy.

Kathryn Martires¹, Shields Callahan, Vitaly Terushkin

¹Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Dermatology Online Journal

|March 23, 2017

Summary

Eosinophilic dermatosis of hematologic malignancy (EDHM) can manifest as itchy, swollen, and blistering skin lesions in patients with chronic lymphocytic leukemia (CLL). Prompt hematologic evaluation is crucial for patients presenting with these dermatologic symptoms.

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Area of Science:

Dermatology
Hematology
Oncology

Background:

Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
Paraneoplastic dermatoses can be associated with underlying malignancies.
Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare skin condition linked to blood cancers.

Observation:

A 68-year-old woman with a history of CLL developed pruritic, edematous, and vesicobullous skin lesions on her face and extremities.
Clinical presentation and histopathologic examination confirmed the diagnosis of EDHM.
The patient's symptoms developed over several months.

Findings:

The diagnosis of eosinophilic dermatosis of hematologic malignancy (EDHM) was established based on clinical and histopathological findings.
EDHM is considered a paraneoplastic disorder resulting from immune dysregulation.
A potential association between EDHM and more aggressive CLL was noted.

Implications:

Patients with EDHM require thorough hematologic and oncologic evaluation to assess for underlying or evolving hematologic malignancies.
Early recognition and management of EDHM may be linked to the control of the underlying cancer.
Further research into the pathogenesis of EDHM is warranted to understand the immune dysregulation involved.