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ILC-poiesis: Making Tissue ILCs from Blood
Jenny Mjösberg1, Luca Mazzurana2
1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Clinical and Experimental Medicine, Linköping University, 581 83 Linköping, Sweden.
Immunity
|March 23, 2017
Summary
Human innate lymphoid cell precursors (ILCPs) reside in peripheral blood. These ILCPs, found within CD117+ innate lymphoid cells, can develop into all ILC subsets, clarifying innate lymphoid cell development.
Area of Science:
- Immunology
- Hematopoiesis
- Cell Biology
Background:
- Human innate lymphoid cell (ILC) development is not well understood.
- Identifying precursor populations is crucial for understanding ILC biology.
Purpose of the Study:
- To characterize the developmental origins of human innate lymphoid cells.
- To identify precursor populations within the peripheral blood.
Main Methods:
- Analysis of human peripheral blood mononuclear cells.
- Phenotypic characterization of CD117+ ILCs.
- In vitro and in vivo differentiation assays.
Main Results:
- Human peripheral blood CD117+ ILCs contain ILC precursors (ILCPs).
- These ILCPs originate from hematopoietic stem cells.
- Peripheral blood ILCPs can differentiate into all known ILC subsets.
Conclusions:
- Peripheral blood harbors a readily accessible source of ILC precursors.
- This finding provides critical insights into human ILC development and potential therapeutic strategies.
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