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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
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Related Experiment Video

Updated: Mar 5, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
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Elevated MIF-2 levels predict mortality in critically ill patients.

Julia Pohl1, Ulrike B Hendgen-Cotta1, Pia Stock1

  • 1University Hospital Essen, West German Heart and Vascular Center, Department of Cardiology and Vascular Medicine, Hufelandstr. 55, 45147 Essen, Germany.

Journal of Critical Care
|March 23, 2017
PubMed
Summary
This summary is machine-generated.

Plasma D-dopachrome tautomerase (MIF-2) levels are elevated in critically ill patients. Higher MIF-2 indicates greater disease severity and increased mortality risk, suggesting its prognostic value in critical care.

Keywords:
ICUMIF-2Organ failurePrognosisSepsis

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Area of Science:

  • Biochemistry
  • Critical Care Medicine
  • Immunology

Background:

  • D-dopachrome tautomerase (MIF-2) is structurally homologous to macrophage migration inhibitory factor (MIF).
  • Elevated circulating MIF-2 has been observed in sepsis, severe burns, and post-surgery.
  • The prognostic significance of MIF-2 in critically ill patients requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic value of MIF-2 in critically ill patients.
  • To compare MIF-2 levels in intensive care unit (ICU) patients with healthy controls.
  • To assess the correlation of MIF-2 with disease severity and organ damage markers.

Main Methods:

  • Studied 72 critically ill patients upon ICU admission.
  • Assessed plasma levels of MIF-2 and MIF.
  • Collected clinical data, laboratory parameters, and mortality information.

Main Results:

  • Critically ill patients exhibited significantly higher MIF-2 and MIF levels than healthy controls.
  • MIF-2 levels correlated with APACHE II scores, indicating association with disease severity.
  • Elevated MIF-2 correlated with organ damage biomarkers but was independent of kidney disease status.
  • High plasma MIF-2 levels were associated with distinctly elevated mortality.

Conclusions:

  • MIF-2 is elevated in critically ill patients.
  • MIF-2 levels correlate with organ damage and disease severity.
  • MIF-2 shows potential as a prognostic marker in critical illness.