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Progress in nonviral gene therapy for breast cancer and what comes next?

Giulia Bottai1, Marta Truffi2, Fabio Corsi3

  • 1a Oncology Experimental Therapeutics , IRCCS Clinical and Research Institute Humanitas , Rozzano ( Milan ), Italy.

Expert Opinion on Biological Therapy
|March 24, 2017
PubMed
Abstract

Insights

Gene therapy offers promising breast cancer treatments by correcting genes and modulating expression. Immune-based approaches and innovative strategies like genome editing show potential, but challenges remain for clinical application.

Area of Science:

  • Oncology
  • Genetics
  • Immunology

Background:

  • Gene therapy is a promising strategy for breast cancer treatment.
  • The tumor immune microenvironment is crucial for cancer progression and offers targets for gene therapy.
  • Gene therapy approaches include gene transfer, RNA interference (RNAi), and epigenetic regulation.

Purpose of the Study:

  • To review gene therapy delivery systems and therapeutic approaches for breast cancer.
  • To highlight innovative strategies and clinical trial applications of gene therapy in breast cancer.
  • To discuss the potential and challenges of gene therapy in breast cancer treatment.

Main Methods:

  • Focus on nonviral vectors for gene delivery.
  • Description of gene transfer, RNA interference (RNAi), and epigenetic regulation techniques.
  • Review of innovative strategies like genome editing and stem cell-based systems.

Main Results:

  • Gene therapy, including RNAi, shows potential for breast cancer treatment.
  • Immune-based gene therapy approaches are emerging as therapeutic opportunities.
  • Clinical trials are investigating gene therapy for breast cancer.

Conclusions:

  • Gene therapy holds significant potential for breast cancer research and treatment.
  • Further research is needed to advance RNAi-based therapeutics and overcome clinical challenges.
  • Genome editing, stem cell-based systems, and immune-based approaches may translate gene therapy into clinical practice for selected patients.
Keywords:
Breast cancerclinical trialsgene therapyimmunotherapynonviral nanovectorsvaccine

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