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Related Experiment Videos

Avian sarcoma viruses.

L H Wang1, H Hanafusa

  • 1Rockefeller University, New York, NY 10021.

Virus Research
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Avian sarcoma viruses (ASVs) utilize various transforming genes, including src, fps, yes, and ros, which encode tyrosine-specific protein kinases. These viral oncoproteins are crucial for cell transformation, though not always sufficient, and interact with cellular components.

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Area of Science:

  • Virology
  • Molecular Biology
  • Oncology

Background:

  • Avian sarcoma viruses (ASVs) are categorized into four groups based on their transforming genes: src, fps, yes, and ros.
  • These transforming genes are acquired from chicken cellular DNA by avian retroviruses through recombination.
  • ASVs encode various transforming proteins, including p60src and gag-fusion proteins (P140/130gag-fps, P90gag-yes, P68gag-ros).

Purpose of the Study:

  • To investigate the nature and function of transforming genes in ASVs.
  • To characterize the protein kinase activity associated with ASV transforming proteins.
  • To explore the relationship between viral oncoproteins, cellular proto-oncogenes, and the process of cell transformation.

Main Methods:

  • Classification of ASV isolates based on viral genome transforming sequences.

Related Experiment Videos

  • Identification and characterization of viral transforming proteins and their associated kinase activities.
  • Analysis of cellular proto-oncogenes (c-src, c-fps, c-yes, c-ros) and their potential roles in transformation.

    • Main Results:

    • All ASV transforming proteins exhibit tyrosine-specific protein kinase activity.
    • p60src and P68gag-ros are membrane-associated, while P140/130gag-fps and P90gag-yes are loosely associated with the plasma membrane.
    • While kinase activity is essential, it's not sufficient for transformation; specific domains like the N-terminal of p60src are crucial.
    • Cellular proto-oncogenes c-src, c-fps, and c-yes also possess tyrosine kinase activity, and c-ros may encode a growth factor receptor.

    Conclusions:

    • ASV transforming proteins, through their tyrosine kinase activity, play a critical role in cell transformation.
    • Specific structural features of viral oncoproteins, such as membrane binding domains, are essential for their transforming ability.
    • Cellular proto-oncogenes are related to viral transforming genes and can be converted into transforming genes through structural alterations, suggesting a common mechanism in oncogenesis.