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Updated: Mar 5, 2026
Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 3. Aerobiology
Published on: October 3, 2016
Implementing a negative-pressure isolation ward for a surge in airborne infectious patients
Shelly L Miller1, Nicholas Clements1, Steven A Elliott2
1Department of Mechanical Engineering, University of Colorado, Boulder, CO; National Center for Occupational Health and Infection Control, Patient Care Services, Veterans Health Administration, Gainesville, FL.
Background:
During a large-scale airborne infectious disease outbreak, the number of patients needing hospital-based health care services may exceed available negative-pressure isolation room capacity.
Methods:
To test one method of increasing hospital surge capacity, a temporary negative-pressure isolation ward was established at a fully functioning hospital. Negative pressure was achieved in a 30-bed hospital ward by adjusting the ventilation system. Differential pressure was continuously measured at 22 locations, and ventilation airflow was characterized throughout the ward.
Results:
The pressure on the test ward relative to the main hospital hallway was -29 Pa on average, approximately 10 times higher than the Centers for Disease Control and Prevention guidance for airborne infection control. No occurrences of pressure reversal occurred at the entrances to the ward, even when staff entered the ward. Pressures within the ward changed, with some rooms becoming neutrally or slightly positively pressurized.
Conclusions:
This study showed that establishing a temporary negative-pressure isolation ward is an effective method to increase surge capacity in a hospital.
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