Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

4.9K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
4.9K
The Blood-brain Barrier00:49

The Blood-brain Barrier

54.2K
Overview
54.2K
Physiological Barriers01:25

Physiological Barriers

5.5K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.5K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

1.9K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.9K
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

43.3K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
43.3K
Capillary Exchange01:28

Capillary Exchange

12.0K
The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Levetiracetam inhibits the Na<sup>+</sup> HCO<sub>3</sub> <sup>-</sup> transporter Ncbe/NBCn2 (Slc4a10) in the choroid plexus of mice.

Acta physiologica (Oxford, England)·2026
Same author

Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice.

Cell biochemistry and function·2026
Same author

NH<sub>4</sub>Cl-induced metabolic acidosis increases the abundance of HCO<sub>3</sub> <sup>-</sup> transporters in the choroid plexus of mice.

Frontiers in physiology·2024
Same author

Mechanisms of cerebrospinal fluid secretion by the choroid plexus epithelium: Application to various intracranial pathologies.

Clinical anatomy (New York, N.Y.)·2024
Same author

Water channels in the brain and spinal cord-overview of the role of aquaporins in traumatic brain injury and traumatic spinal cord injury.

Frontiers in cellular neuroscience·2024
Same author

The Cyst Epithelium in Polycystic Kidney Disease Patients Displays Normal Apical-Basolateral Cell Polarity.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Mar 5, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
06:45

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

5.7K

Transport across the choroid plexus epithelium.

Jeppe Praetorius1, Helle Hasager Damkier2,3

  • 1Department of Biomedicine, Health, Aarhus University, Aarhus, Denmark; and jp@biomed.au.dk.

American Journal of Physiology. Cell Physiology
|March 24, 2017
PubMed
Summary

The choroid plexus is crucial for cerebrospinal fluid production and brain development. Ongoing research explores its role in CNS disorders, immune cell entry, and drug delivery, challenging established theories.

Keywords:
barrier functioncerebrospinal fluidchoroid plexusfluid secretionvectorial transport

More Related Videos

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

15.0K
Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability
10:56

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Published on: June 7, 2022

6.2K

Related Experiment Videos

Last Updated: Mar 5, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
06:45

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

5.7K
A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

15.0K
Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability
10:56

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Published on: June 7, 2022

6.2K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Physiology

Background:

  • The choroid plexus epithelium is a highly secretory tissue within the brain ventricles.
  • It is widely recognized as the primary source of cerebrospinal fluid (CSF).
  • This function is critical for understanding neurological conditions affecting fluid and ionic balance.

Purpose of the Study:

  • To review current research on choroid plexus physiology.
  • To highlight emerging areas of investigation.
  • To discuss ongoing controversies regarding its functions.

Main Methods:

  • Literature review of recent studies on choroid plexus research.
  • Synthesis of findings from various investigations.
  • Analysis of conflicting data and established concepts.

Main Results:

  • The choroid plexus's role in CSF production remains a primary focus but is under re-examination.
  • New research highlights its importance in CNS development via secreted mediators.
  • The choroid plexus serves as a pathway for immune cells and pathogens into the brain.
  • It is investigated as a potential route for drug delivery across the blood-brain barrier.

Conclusions:

  • The choroid plexus is a multifaceted tissue with roles beyond CSF secretion.
  • Its involvement in CNS development, immunity, and therapeutic delivery is a key area of current research.
  • Further investigation is needed to resolve controversies and fully elucidate choroid plexus functions.