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TET2 mutation in diffuse large B-cell lymphoma
Yoko Kubuki1, Takumi Yamaji, Tomonori Hidaka
1Department of Transfusion and Cell Therapy, University of Miyazaki Hospital.
Abstract:
Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. TET2 mutation presents across disease entities and was reported in lymphoid malignancies. We investigated TET2 mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.
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