Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.3K
Overview
85.3K
Cross-reactivity00:42

Cross-reactivity

33.6K
Overview
33.6K
Blood Transfusion01:15

Blood Transfusion

2.7K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.7K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.2K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.2K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.9K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety in Robotic Kidney Transplant for All-Comers: Does Body Mass Index Need to be Considered?

Kidney360·2026
Same author

Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

JAMA surgery·2026
Same author

The road to 100: single center experience with the first 100 consecutive robotic kidney transplants.

Journal of robotic surgery·2026
Same author

Postoperative complications after liver transplantation: Are we making progress?

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2025
Same author

Contemporary Clinical Utilization of Radioembolization with Immune Checkpoint Inhibitors as First-Line Treatment in HCC: Real-World Report on Safety and Outcomes.

Cancers·2025
Same author

Diversity, equity, inclusion, and belonging in organ transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025
Same journal

Comparative Distribution of High-Risk Human Papillomavirus (HPV) Genotypes in India vs World Health Organization Regions and Countries: Implications for HPV Vaccination.

Ochsner journal·2026
Same journal

Development and Implementation of a Radiation Safety Screening Protocol for a Clinical Study Using Amyloid Positron Emission Tomography Imaging.

Ochsner journal·2026
Same journal

A History of Vena Cava Interruption to Treat Pulmonary Embolism: The Ben Hogan Case.

Ochsner journal·2026
Same journal

Type 1 Collagen/Poly-L-Lactic Acid Biocomposite Augmentation of a Nontraumatic Symptomatic Complete Rotator Cuff Tear.

Ochsner journal·2026
Same journal

Spurious Plasma Adrenocorticotropic Hormone Level in a Patient With Adrenal Cushing Syndrome.

Ochsner journal·2026
Same journal

Revumenib-Induced QTc Prolongation Leading to Multiple Episodes of Torsades de Pointes and Ventricular Arrhythmias.

Ochsner journal·2026
See all related articles

Related Experiment Video

Updated: Mar 5, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.5K

Antibody-Mediated Rejection: A Review.

Jorge Carlos Garces1, Sixto Giusti2, Catherine Staffeld-Coit3

  • 1Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.

Ochsner Journal
|March 24, 2017
PubMed
Summary
This summary is machine-generated.

Antibody-mediated rejection (AMR) poses a significant threat to organ transplant success. Current treatments show variable efficacy, highlighting the need for new therapies and rigorous clinical trials to improve long-term allograft function.

Keywords:
Desensitization–immunologicHLA antigensgraft rejectionkidney transplantationtransplantation tolerance

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

17.1K

Related Experiment Videos

Last Updated: Mar 5, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.5K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

17.1K

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Clinical Pathology

Background:

  • Chronic antibody injury is a major challenge in allograft survival, driving active research into antibody-mediated rejection (AMR).
  • Advances in understanding molecular and histologic changes have improved insights into AMR and potential interventions.
  • However, incomplete knowledge of certain pathways limits the effectiveness of current rejection treatments.

Purpose of the Study:

  • To review current diagnostic criteria for AMR.
  • To discuss AMR paradigms, desensitization, and treatment strategies.
  • To highlight the need for improved therapeutic approaches for AMR.

Main Methods:

  • Comprehensive review of existing literature on AMR diagnosis and treatment.
  • Analysis of current diagnostic criteria and therapeutic strategies.
  • Evaluation of the efficacy of various treatment modalities.

Main Results:

  • Chronic antibody-mediated endothelial injury leads to transplant glomerulopathy, with clinical signs including proteinuria and elevated creatinine.
  • Treatments like plasmapheresis (PLEX), immunoadsorption (IA), IVIG, and B-cell depleting agents are used, with some benefit noted for PLEX, IA, rituximab, and bortezomib in small trials.
  • Bortezomib has shown limited long-term allograft benefit in follow-up studies, and no AMR treatments are FDA-approved.

Conclusions:

  • Alloimmune responses, despite advanced antibody detection, remain a barrier to long-term allograft function.
  • Current AMR therapies yield variable and often suboptimal results, hindering standardized treatment protocols.
  • Future research requires randomized controlled trials to identify surrogate markers and enhance therapeutic efficacy for AMR.