Meckel Diverticulum Harboring a Rare Gastrointestinal Stromal Tumor
Related Experiment Video
Updated: Mar 5, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
Andrew C Berry1, Rahman Nakshabendi2, Ozdemir Kanar2
1Department of Medicine, University of South Alabama, Mobile, AL.
Background:
Tumors within a Meckel diverticulum are a rare complication observed in only 0.5%-3.2% of symptomatic cases. The majority of tumors are benign, but some malignant tumors, such as gastrointestinal stromal tumors (GISTs) can occur.
Case Report:
We report the case of a 48-year-old female who presented with severe abdominal pain and nausea and was found to have a GIST arising from a Meckel diverticulum.
Conclusion:
The differential diagnosis of a pelvic mass in a middle-aged female presenting with gastrointestinal symptoms must remain broad. With an atypical presentation site, distinguishing benign tumors from malignant tumors such as GISTs is of paramount importance.
Insights
Gastrointestinal stromal tumors (GISTs) are rare malignant tumors that can arise in a Meckel diverticulum. Early diagnosis is crucial for distinguishing GISTs from benign tumors in patients with gastrointestinal symptoms.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Meckel diverticulum tumors are rare, occurring in 0.5%-3.2% of symptomatic cases.
- While most Meckel diverticulum tumors are benign, malignant types like GISTs can occur.
