Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gibbs Free Energy02:39

Gibbs Free Energy

40.1K
One of the challenges of using the second law of thermodynamics to determine if a process is spontaneous is that it requires measurements of the entropy change for the system and the entropy change for the surroundings. An alternative approach involving a new thermodynamic property defined in terms of system properties only was introduced in the late nineteenth century by American mathematician Josiah Willard Gibbs. This new property is called the Gibbs free energy (G) (or simply the free...
40.1K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

13.3K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
13.3K
Sampling Theorem01:15

Sampling Theorem

1.5K
In signal processing, the analysis of continuous-time signals, denoted as x(t), often involves sampling techniques to convert these signals into discrete-time signals. This process is essential for digital representation and manipulation. A critical component in sampling is the train of impulses, characterized by the sampling interval and the sampling frequency. The relationship between these parameters and the original signal's properties dictates the success of the sampling process.
1.5K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

15.3K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
15.3K
Graphs of Functions01:30

Graphs of Functions

409
Graphs of functions provide a visual representation of how output values change in response to varying inputs. Each point on the graph corresponds to an ordered pair, where the x-coordinate (independent variable) determines the horizontal position and the y-coordinate (dependent variable) determines the vertical position. Linear functions like y = x give a straight line, indicating a constant rate of change.Nonlinear functions display more complex behaviors. Even power functions generate...
409
Sequence Networks of Rotating Machines01:24

Sequence Networks of Rotating Machines

511
A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic Factor Analysis for Sparse and Irregular Longitudinal Data: An Application to Metabolite Measurements in a COVID-19 Study.

Statistics in medicine·2026
Same author

Validation of PREdiction of DELIRium in ICu patients (PRE-DELIRIC) model for ICU delirium in general ICU and patients with liver disease: a retrospective cohort study.

Journal of intensive care·2025
Same author

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data.

Molecular oncology·2025
Same author

Dynamic factor analysis with dependent Gaussian processes for high-dimensional gene expression trajectories.

Biometrics·2024
Same author

Development and validation of a reliable DNA copy-number-based machine learning algorithm (CopyClust) for breast cancer integrative cluster classification.

Scientific reports·2024
Same author

Combining chains of Bayesian models with Markov melding.

Bayesian analysis·2023
Same journal

Classification Under Local Differential Privacy with Model Reversal and Model Averaging.

Journal of machine learning research : JMLR·2026
Same journal

Sparse Semiparametric Discriminant Analysis for High-dimensional Zero-inflated Data.

Journal of machine learning research : JMLR·2026
Same journal

Heterogeneity-aware Clustered Distributed Learning for Multi-source Data Analysis.

Journal of machine learning research : JMLR·2026
Same journal

Unsupervised Tree Boosting for Learning Probability Distributions.

Journal of machine learning research : JMLR·2026
Same journal

A Two-Stage Penalized Least Squares Method for Constructing Large Systems of Structural Equations.

Journal of machine learning research : JMLR·2026
Same journal

Bayesian Multinomial Logistic Normal Models through Marginally Latent Matrix-T Processes.

Journal of machine learning research : JMLR·2026
See all related articles

Related Experiment Video

Updated: Mar 5, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K

A Gibbs Sampler for Learning DAGs.

Robert J B Goudie1, Sach Mukherjee2

  • 1Medical Research Council Biostatistics Unit Cambridge CB2 0SR, UK.

Journal of Machine Learning Research : JMLR
|March 24, 2017
PubMed
Summary
This summary is machine-generated.

We developed a new Gibbs sampler for learning directed acyclic graph (DAG) structures. This efficient method improves upon standard algorithms, enabling faster exploration of complex graph spaces for better structure learning.

Keywords:
Bayesian networksDAGsGibbs samplingMarkov chain Monte Carlostructure learningvariable selection

More Related Videos

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.7K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.1K

Related Experiment Videos

Last Updated: Mar 5, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.7K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.1K

Area of Science:

  • Machine Learning
  • Statistical Modeling
  • Computational Statistics

Background:

  • Structure learning for directed acyclic graph (DAG) models is crucial in many fields.
  • Existing Markov chain Monte Carlo (MCMC) methods, like random-walk Metropolis-Hastings samplers, often exhibit slow mixing rates in large graph spaces.

Purpose of the Study:

  • To propose a novel Gibbs sampler for efficient structure learning in DAG models.
  • To address the slow mixing problem of existing MCMC algorithms in DAG structure learning.

Main Methods:

  • Developed a Gibbs sampler that draws entire sets of parents for multiple nodes simultaneously.
  • The sampler utilizes conditional distributions related to variable selection, where candidate parents act as covariates.
  • Employed empirical evaluations using simulated and real-world data.

Main Results:

  • The proposed Gibbs sampler demonstrates efficient exploration of graph space, leading to faster mixing.
  • Empirical results show robust performance across diverse settings.
  • The new method outperforms existing Bayesian and frequentist approaches for DAG structure learning.

Conclusions:

  • The novel Gibbs sampler offers an efficient and effective approach for DAG structure learning.
  • The method provides faster mixing and robust results compared to existing techniques.
  • Empirical findings offer insights into the comparative advantages of Bayesian versus constraint-based structure learning methods.