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Related Experiment Video

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Orthotopic Injection of Breast Cancer Cells into the Mice Mammary Fat Pad
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Breast Carcinosarcomas.

Savaş Yakan1, Erdem Sarı1, Nazif Erkan1

  • 1Department of General Surgery, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.

The Journal of Breast Health
|March 24, 2017
PubMed
Summary

Breast carcinosarcomas are rare, aggressive tumors. This study found survival rates similar to epithelial tumors, contrary to literature, suggesting a need for more research on these challenging breast cancers.

Keywords:
Breastcarcinosarcomametaplasia

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Breast Cancer Research

Background:

  • Breast carcinosarcomas are rare, aggressive tumors with unclear optimal treatment and classification due to low incidence.
  • Limited literature exists on managing these difficult-to-diagnose breast malignancies.

Purpose of the Study:

  • To evaluate outcomes of patients operated on for breast carcinosarcoma.
  • To compare findings with existing literature on breast carcinosarcoma prognosis.

Main Methods:

  • Retrospective analysis of ten patients diagnosed with breast carcinosarcoma between January 2000 and March 2013.
  • Surgical procedures included modified radical mastectomy, lumpectomy, and breast-conserving surgery with sentinel lymph node biopsy.

Main Results:

  • The mean patient age was 59.7 years.
  • TNM staging revealed 2 patients at stage 1, 6 at stage 2, and 2 at stage 3.
  • The 60-month disease-free survival rate was 52.5%, and overall survival was 53.3%. Four patients died during follow-up.

Conclusions:

  • Prognosis of breast carcinosarcomas is often considered poor, similar to triple-negative epithelial tumors.
  • Contrary to expectations, this study's survival rates by stage did not differ significantly from epithelial tumors.
  • Prospective studies with larger patient cohorts are necessary to further elucidate breast carcinosarcoma outcomes.