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Pleural amyloidosis imitating pleural malignancy.

Frith Coolbear¹, Ana-Maria Bilawich¹, Jonathan Tongson²

¹Department of Radiology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.

Respiratory Medicine Case Reports

|March 24, 2017

Summary

This summary is machine-generated.

Pleural amyloidosis is a rare cause of diffuse pleural thickening, often mistaken for cancer. This case highlights the diagnostic challenges in differentiating pleural amyloid from malignant pleural disease.

Keywords:

Amyloid Mesothelioma Pleura

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Area of Science:

Pulmonology
Pathology
Radiology

Background:

Diffuse pleural thickening is a common finding on chest imaging.
Malignant pleural disease, such as mesothelioma and metastases, are primary concerns.
Rare conditions can mimic malignant pleural disease, posing diagnostic challenges.

Observation:

An 83-year-old man presented with dyspnea and malaise.
CT chest revealed bilateral circumferential pleural thickening.
Initial imaging findings were highly suspicious for pleural malignancy.

Findings:

Histopathology of a pleural biopsy confirmed pleural amyloidosis.
Pleural amyloidosis presented as diffuse pleural thickening.
Distinguishing amyloid from malignancy based on imaging alone is difficult.

Implications:

Pleural amyloidosis should be considered in the differential diagnosis of diffuse pleural thickening.
Advanced imaging and histopathology are crucial for accurate diagnosis.
Recognizing rare causes of pleural thickening improves patient management and outcomes.