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Aspirin and risk of multiple myeloma in adults: A systematic review and meta-analysis

Shing Fung Lee1, Ting Ying Ng1, Frank Chi Sing Wong1

  • 1Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong, SAR, China.

Leukemia Research Reports
|March 24, 2017
PubMed

Insights

Regular aspirin use does not appear to significantly alter the risk of developing multiple myeloma, a rare plasma cell cancer. This systematic review found no conclusive evidence linking aspirin consumption to altered multiple myeloma incidence.

Area of Science:

  • Hematology
  • Oncology
  • Epidemiology

Background:

  • Multiple myeloma is a malignancy originating from plasma cells.
  • Previous research suggested a potential role for aspirin in modifying multiple myeloma risk.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies.
  • To investigate the association between regular aspirin use and the risk of multiple myeloma.

Main Methods:

  • Systematic review and meta-analysis of observational studies.
  • Inclusion of five studies encompassing 332,660 adult participants.
  • Evaluation of pooled hazard ratios and odds ratios.

Main Results:

  • The pooled hazard ratio for multiple myeloma risk associated with aspirin use was 0.90 (95% CI = 0.58-1.39, P=0.638).
  • Results from case-control studies showed similar trends.
  • No statistically significant association was found between aspirin use and multiple myeloma risk.

Conclusions:

  • Current evidence does not support a significant link between regular aspirin use and the risk of developing multiple myeloma.
  • Further research may be warranted to fully elucidate any potential complex interactions.
Keywords:
AnalgesicsAspirinMeta-analysisMultiple myelomaNeoplasms

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