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5'-Nucleotidase in skin fibroblasts from patients with Duchenne muscular dystrophy
C E Sinclair1, M S Ecob-Prince, R J Pennington
1Department of Neurochemistry, Newcastle General Hospital, Newcastle upon Tyne, England.
Abstract:
The 5'-nucleotidase of plasma membranes of cultured skin fibroblasts from patients with Duchenne muscular dystrophy had a reduced affinity for its substrate, 5'-AMP. The Arrhenius plot of the temperature dependence of this enzyme activity was normal. There was no difference between patients and controls in the specific 5'-nucleotidase activity in the whole cell homogenates.

