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Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Lipids: Dietary Sources and Requirements01:18

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Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
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Related Experiment Video

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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Preconception maternal lipoprotein levels in relation to fecundability.

Sarah J Pugh1, Enrique F Schisterman1, Richard W Browne2

  • 1Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA.

Human Reproduction (Oxford, England)
|March 24, 2017
PubMed
Summary

Abnormal maternal lipid levels, including high total cholesterol, LDL-C, and triglycerides, and low HDL-C, are linked to reduced fecundability. These findings suggest lipid management may improve fertility outcomes.

Keywords:
cholesterolfecunditylipidslipoproteinpreconceptionpregnancytriglycerides

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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Area of Science:

  • Reproductive Endocrinology
  • Metabolic Health
  • Human Fertility Studies

Background:

  • Subfecundity affects 7-15% of the population.
  • Lipid disorders are hypothesized to impact fertility due to cholesterol's role in steroid hormone synthesis.
  • Few human studies have investigated preconception lipid levels and fecundity.

Purpose of the Study:

  • To determine if maternal preconception lipid levels are associated with fecundability.
  • To explore the relationship between specific lipoproteins and the time to pregnancy.

Main Methods:

  • Secondary analysis of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial.
  • 1228 women attempting pregnancy were recruited.
  • Preconception lipoproteins were measured and dichotomized using clinical cut-points.

Main Results:

  • Reduced fecundability was observed for all abnormal female lipid levels (total cholesterol, LDL-C, HDL-C, triglycerides).
  • Elevated total cholesterol (≥200 mg/dl) was associated with 24-29% reduced fecundability.
  • Abnormal lipoprotein levels decreased conception probability by 19-36% per cycle.

Conclusions:

  • Abnormal preconception lipid profiles are associated with reduced female fecundability.
  • Modifiable lipid levels may represent a target for improving fertility.
  • Obesity and central adiposity may confound or mediate the relationship between lipids and fecundability.