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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
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MicroRNAs and lipid metabolism
Binod Aryal1, Abhishek K Singh, Noemi Rotllan
1Vascular Biology and Therapeutics Program, Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Current Opinion in Lipidology
|March 24, 2017
Summary
MicroRNAs regulate cholesterol metabolism and cardiometabolic disorders. Recent findings highlight miR-33
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiovascular Research
Background:
- MicroRNAs (miRNAs) play a crucial role in regulating lipoprotein metabolism.
- Dysregulation of miRNAs is linked to metabolic syndrome, obesity, and atherosclerosis.
Purpose of the Study:
- To review recent findings on miRNAs in controlling LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) metabolism.
- To highlight the contribution of miRNAs to cardiometabolic disorders.
Main Methods:
- Literature review of recent studies on miRNA function in lipid metabolism.
- Analysis of findings from Genome-Wide Association Studies (GWAS).
Main Results:
- miR-122 and miR-33 are key regulators of lipid metabolism.
- miR-33 also regulates macrophage activation, mitochondrial metabolism, vascular homeostasis, and cardiac adaptation.
- GWAS identified single-nucleotide polymorphisms near miRNA genes associated with abnormal lipid levels.
- miRNAs like miR-148a and miR-128-1 target proteins regulating cholesterol metabolism (e.g., LDLR, ABCA1).
Conclusions:
- MicroRNAs are critical regulators of cholesterol metabolism and potential therapeutic targets for atherosclerosis.
- Novel miRNAs involved in LDL metabolism and cardiovascular homeostasis have been identified.
- miR-33 has roles beyond lipid metabolism, influencing cardiovascular homeostasis.
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