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IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME CAUSING PROGRESSIVE OPTIC NERVE EDEMA IN CRYPTOCOCCAL MENINGITIS
Astrid C Werner1, Laurel N Vuong2, Thomas R Hedges2
1Department of Ophthalmology, Tufts New England Eye Center, Boston, Massachusetts.
Retinal Cases & Brief Reports
|March 24, 2017
Summary
A human immunodeficiency virus-positive patient with cryptococcal meningitis developed optic disk edema. This condition, potentially a rare form of immune reconstitution inflammatory syndrome, resolved with steroid treatment.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Neurology
Background:
- Cryptococcal meningitis is a serious opportunistic infection in human immunodeficiency virus (HIV)-positive individuals.
- Immune reconstitution inflammatory syndrome (IRIS) can occur during antiretroviral therapy, leading to paradoxical worsening of infections or new inflammatory conditions.
- Optic nerve involvement in IRIS, particularly without uveitis, is uncommon.
