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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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mirMachine: A One-Stop Shop for Plant miRNA Annotation
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A compilation of Web-based research tools for miRNA analysis.

Vaibhav Shukla, Vinay Koshy Varghese, Shama Prasada Kabekkodu

    Briefings in Functional Genomics
    |March 24, 2017
    PubMed
    Summary

    MicroRNAs (miRNAs) regulate gene expression and are crucial in diseases like cancer. This review assesses web-based bioinformatics tools for miRNA analysis, accessible without programming knowledge.

    Keywords:
    databasesdiseasesmicroRNAonline tools

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    Area of Science:

    • Molecular Biology
    • Bioinformatics
    • Genetics

    Background:

    • MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression post-transcriptionally.
    • miRNAs play significant roles in various pathophysiological conditions, notably cancer.
    • The discovery of miRNAs has led to the development of numerous analytical tools.

    Purpose of the Study:

    • To provide a comprehensive assessment of web-based tools for miRNA analysis.
    • To highlight tools that do not require prior knowledge of computing languages.
    • To aid researchers in exploring miRNA detection, expression, function, and target prediction.

    Main Methods:

    • Review and assessment of existing web-based bioinformatics tools for miRNA analysis.
    • Focus on tools accessible to users without programming expertise.
    • Categorization of tools based on their applications (e.g., detection, expression, target prediction).

    Main Results:

    • A wide array of bioinformatics tools are available for various miRNA analyses.
    • Many user-friendly, web-based tools exist, catering to researchers with limited computational backgrounds.
    • These tools facilitate diverse applications including miRNA detection, expression profiling, functional analysis, and target prediction.

    Conclusions:

    • Web-based bioinformatics tools offer accessible solutions for miRNA research.
    • The reviewed tools empower researchers to investigate miRNA roles in biological processes and diseases like cancer.
    • These resources are valuable for both basic and advanced miRNA-related studies.