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Protein Networks

Protein Networks

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

Protein and Protein Structures

Protein and Protein Structures

Conservation of Protein Domains

Conservation of Protein Domains

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Related Experiment Video

Updated: Mar 5, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

ProtVista: visualization of protein sequence annotations.

Xavier Watkins^1,2, Leyla J Garcia¹, Sangya Pundir¹

¹EMBL-EBI, Hinxton, UK.

Bioinformatics (Oxford, England)

|March 24, 2017

Summary

This summary is machine-generated.

ProtVista offers a powerful way to visualize protein data from UniProt, aiding researchers in understanding complex information. This tool helps uncover patterns related to protein function and disease associations.

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Last Updated: Mar 5, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis

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Published on: July 12, 2022

A Protocol for Computer-Based Protein Structure and Function Prediction

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Published on: November 3, 2011

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Area of Science:

Bioinformatics
Computational Biology
Molecular Biology

Background:

Protein sequence data from UniProt Knowledgebase, experimental proteomics, and variation datasets are complex.
Interpreting these large, interconnected datasets presents a significant challenge for researchers.

Purpose of the Study:

To introduce ProtVista, a comprehensive visualization tool for protein sequence features.
To facilitate the understanding of complex protein data and its implications for function and disease.

Main Methods:

ProtVista is implemented as a JavaScript component.
The tool is available as an open-source project under the Apache 2 License.

Main Results:

ProtVista provides graphical representations of protein sequence features.
It integrates data from UniProt Knowledgebase, experimental proteomics, and variation datasets.

Conclusions:

Integrative visualization tools like ProtVista are essential for researchers.
ProtVista aids in discovering patterns affecting protein function and disease associations.