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Related Concept Videos

Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Genetic Material01:20

Genetic Material

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Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

19.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.0K
Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K

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Related Experiment Video

Updated: Mar 5, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

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DNA Compass: a secure, client-side site for navigating personal genetic information.

Charles Curnin1, Assaf Gordon1, Yaniv Erlich1,2,3

  • 1New York Genome Center, New York, NY, USA.

Bioinformatics (Oxford, England)
|March 24, 2017
PubMed
Summary
This summary is machine-generated.

DNA Compass is a free website that helps the public understand their personal genomic data. It allows users to easily explore genetic variants and their associated scientific information securely on their own computer.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Genetic Genealogy

Background:

  • Growing public access to raw genomic data through direct-to-consumer companies and large-scale projects.
  • Computational skill and terminal access are barriers for the general public to analyze personal genomic data.

Purpose of the Study:

  • To empower the public with a user-friendly tool for navigating personal genomic information.
  • To provide accessible explanations of genetic variants and their scientific context.

Main Methods:

  • Development of the DNA Compass website (https://compass.dna.land).
  • Implementation of a client-side approach where genotype data remains on the user's computer for security and performance.
  • Integration of variant querying for over 1658 markers and millions of single nucleotide polymorphisms (SNPs).

Main Results:

  • DNA Compass enables users to query their genomic variants and view genotypes alongside scientific resources.
  • The platform has attracted over 12,000 unique users, primarily from the genetic genealogy community.
  • The client-side data handling ensures enhanced security and performance.

Conclusions:

  • DNA Compass successfully addresses the public's need for accessible personal genomic data analysis.
  • The tool demonstrates utility and has gained significant traction within the genetic genealogy community.
  • Freely available online, DNA Compass promotes broader engagement with genomic information.