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Pathogenesis of meningococcal purpura fulminans

Hervé Lécuyer1,2,3,4,5, Delphine Borgel6,7, Xavier Nassif1,2,3,4,5

  • 1Institut Necker Enfants Malades, 75993 Paris, France.

Pathogens and Disease
|March 24, 2017
PubMed

Insights

Purpura fulminans, a severe complication of meningococcal infections, involves blood clotting and skin necrosis. Targeting meningococcus adhesion to endothelium offers new therapeutic strategies for this condition.

Area of Science:

  • Microbiology
  • Pathology
  • Immunology

Background:

  • Purpura fulminans (PF) is a severe complication of invasive Neisseria meningitidis infections.
  • PF is characterized by dermal microvessel thrombosis leading to hemorrhagic skin necrosis and high mortality.

Purpose of the Study:

  • To review prothrombotic events in meningococcal infections.
  • To discuss the role of Neisseria meningitidis adhesion to endothelium in PF development.

Main Methods:

  • Literature review of prothrombotic events.
  • Analysis of experimental mouse model data on meningococcus-endothelium interaction.

Main Results:

  • Neisseria meningitidis infection triggers prothrombotic events.
  • Meningococcus adhesion to endothelium is critical for PF lesion development.

Conclusions:

  • Understanding meningococcus adhesion mechanisms opens new therapeutic avenues for PF.
  • Targeting endothelial adhesion may mitigate PF complications in meningococcal disease.
Keywords:
Neisseria meningitidiscoagulationpurpura fulminans

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