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TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration

Ron Goldner1, Avraham Yaron1

  • 1Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.

Neuron
|March 24, 2017
PubMed

Abstract:

SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.

Keywords:
NADSarm1axon degeneration

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