Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

68.2K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Powered Ultrastretchable Microstructured Intelligent Sensing Technology Based on Tactile Perception of Limb Movement.

ACS omega·2026
Same author

Poly(Vinyl Alcohol)-Carbon Nanotube Self-Adhesive Hydrogels for Wearable Strain Sensors.

Polymers·2025
Same author

DeepValve: The first automatic detection pipeline for the mitral valve in Cardiac Magnetic Resonance imaging.

Computers in biology and medicine·2025
Same author

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging.

Nature communications·2024
Same author

Flexible Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>-Polyurethane Electrodes for Versatile Wearable Applications.

Polymers·2024
Same author

A 3D printable near-infrared triggered hydrogel with MoS<sub>2</sub> as the crosslink center for tissue repair.

Journal of materials chemistry. B·2024

Related Experiment Video

Updated: Mar 5, 2026

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo
04:08

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo

Published on: February 16, 2024

2.3K

How the embryonic chick brain twists.

Zi Chen1,2, Qiaohang Guo3,4, Eric Dai5

  • 1Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA zi.chen@dartmouth.edu.

Journal of the Royal Society, Interface
|March 24, 2017
PubMed
Summary
This summary is machine-generated.

The embryonic chick brain

Keywords:
axial rotationbiomechanicsembryonic developmentleft–right asymmetrytorsion

More Related Videos

Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

1.5K
Author Spotlight: Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior
07:53

Author Spotlight: Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

Published on: May 26, 2023

4.6K

Related Experiment Videos

Last Updated: Mar 5, 2026

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo
04:08

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo

Published on: February 16, 2024

2.3K
Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

1.5K
Author Spotlight: Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior
07:53

Author Spotlight: Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

Published on: May 26, 2023

4.6K

Area of Science:

  • Developmental biology
  • Biophysics
  • Morphogenesis

Background:

  • Early embryonic development involves complex morphological changes.
  • Left-right asymmetry is a fundamental developmental process.
  • The mechanism of embryonic brain torsion is poorly understood.

Purpose of the Study:

  • To elucidate the mechanical origin of embryonic brain torsion.
  • To investigate the role of external forces in brain development.
  • To understand the transfer of left-right asymmetry between organs.

Main Methods:

  • In vitro experiments
  • Physical modeling of embryonic morphology
  • Mechanics analysis
  • Fluid surface tension experiments

Main Results:

  • The vitelline membrane (VM) exerts an external load driving brain torsion.
  • The force exerted by the VM is approximately 10 micronewtons.
  • Asymmetric heart looping mechanically dictates brain torsion chirality.
  • Brain flexure is a prerequisite for torsion.

Conclusions:

  • The vitelline membrane's mechanical load is the primary driver of embryonic brain torsion.
  • Left-right asymmetry is mechanically transferred from the heart to the brain.
  • This study clarifies the physical mechanisms underlying early brain development and asymmetry.