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Updated: Mar 5, 2026

Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
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Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for

Yasuharu Kanki1,2,3, Ryo Nakaki4, Teppei Shimamura5

  • 1Isotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.

Nucleic Acids Research
|March 24, 2017
PubMed
Summary

This study reveals key epigenetic changes during vascular endothelial cell (EC) differentiation from embryonic stem cells. Master regulator genes are dynamically controlled by histone modifications, crucial for EC development and preventing lineage infidelity.

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