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Vitamin E Nicotinate.

Kimbell R Duncan1, Yuichiro J Suzuki2

  • 1Department of Pharmacology and Physiology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA. krd49@georgetown.edu.

Antioxidants (Basel, Switzerland)
|March 25, 2017
PubMed
Summary
This summary is machine-generated.

Vitamin E nicotinate, an ester of vitamin E and niacin, is found endogenously in the heart. Its levels decrease in heart failure, suggesting potential biological importance distinct from other vitamin E forms.

Keywords:
tocopherol nicotinatetocopheryl nicotinatevitamin E nicotinate

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Cardiology

Background:

  • Vitamin E, a lipid-soluble antioxidant, exists naturally as tocopherols and tocotrienols.
  • Common supplemental forms include esterified α-tocopherol (acetate, succinate), which are converted to free α-tocopherol.
  • α-Tocopheryl nicotinate, an ester of vitamin E and niacin, has received less study.

Purpose of the Study:

  • To review and evaluate published literature on α-tocopheryl nicotinate.
  • To highlight potential differences in metabolism and efficacy compared to natural α-tocopherol and α-tocopheryl acetate.
  • To explore the endogenous presence and significance of α-tocopheryl nicotinate.

Main Methods:

  • Literature review of published reports on α-tocopheryl nicotinate.
  • Analysis of metabolomics studies identifying endogenous α-tocopheryl nicotinate.
  • Comparative evaluation of existing data on different vitamin E ester forms.

Main Results:

  • α-Tocopheryl nicotinate is identified as an endogenous compound in the heart.
  • Endogenous levels of α-tocopheryl nicotinate are significantly reduced in heart failure.
  • Potential metabolic and efficacy differences between α-tocopheryl nicotinate and other vitamin E forms are suggested by some studies.

Conclusions:

  • α-Tocopheryl nicotinate may possess unique biological functions and significance, particularly in cardiac health.
  • Further research is warranted to elucidate the specific roles and therapeutic potential of α-tocopheryl nicotinate.
  • This review consolidates current knowledge, emphasizing the need for more data on this specific vitamin E ester.