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Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research
Published on: May 24, 2024
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Modeling Infectious Diseases in the Context of a Developing Immune System
Samrah Masud1, Vincenzo Torraca1, Annemarie H Meijer1
1Institute of Biology, Leiden University, Leiden, The Netherlands.
Current Topics in Developmental Biology
|March 25, 2017
Summary
Zebrafish models reveal how innate immune cells like macrophages and neutrophils combat infections. Studies highlight the microbiome
Area of Science:
- Immunology
- Developmental Biology
- Microbiology
Background:
- Zebrafish are a key model for studying inflammatory disorders and infections.
- They are crucial for understanding innate immune cell differentiation (macrophages, neutrophils).
- Optical transparency and genetic tools in zebrafish embryos aid in studying immune cell interactions.
Purpose of the Study:
- To review insights from developing zebrafish on host responses to microbes.
- To explore the microbiome's role in physiological processes.
- To provide a basis for novel therapeutic strategies against infectious diseases.
Main Methods:
- Utilizing zebrafish models for bacterial, viral, and fungal infections.
- Employing fluorescent labels to track myeloid cell development in embryos.
- Using genetic manipulation to alter immune cell populations.
Main Results:
- Zebrafish models illuminate immune cell specialization and polarization.
- Studies demonstrate the importance of microbiota in immune system training.
- Conservation of immune recognition and defense activation mechanisms is evident.
Conclusions:
- Developing zebrafish offer significant insights into host-microbe interactions.
- Understanding these mechanisms can lead to new treatments for infectious diseases.
- The zebrafish model is highly valuable for biomedical research.
Keywords:
Emergency hematopoiesisHost–pathogen interactionInfectionInflammationInnate immunityMacrophageMicrobiomeMycobacteriumNeutrophilZebrafishMore Related Videos
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