Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy

The design and development of multifunctional nanoplatforms for biomedical applications still remains to be challenging. This review reports the recent advances in aqueous-phase synthesis of iron oxide nanoparticles (Fe₃O₄ NPs) and their composites for magnetic resonance (MR) imaging and photothermal therapy of cancer. Water dispersible and colloidally stable Fe₃O₄ NPs synthesized via controlled coprecipitation route, hydrothermal route and mild reduction route are introduced. Some of key strategies to improve the r₂ relaxivity of Fe₃O₄ NPs and to enhance their uptake by cancer cells are discussed in detail. These aqueous-phase synthetic methods can also be applied to prepare Fe₃O₄ NP-based composites for dual-mode molecular imaging applications. More interestingly, aqueous-phase synthesized Fe₃O₄ NPs are able to be fabricated as multifunctional theranostic agents for multi-mode imaging and photothermal therapy of cancer. This review will provide some meaningful information for the design and development of various Fe₃O₄ NP-based multifunctional nanoplatforms for cancer diagnosis and therapy.