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Highly Modular Bioluminescent Sensors for Small Molecules and Proteins
Qiuliyang Yu1, Rudolf Griss1, Alberto Schena2
1École Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering (ISIC), Lausanne, Switzerland; École Polytechnique Fédérale de Lausanne (EPFL), Institute of Bioengineering, Lausanne, Switzerland; National Centre of Competence in Research (NCCR) Chemical Biology, Lausanne, Switzerland.
This study introduces a novel, modular bioluminescent sensor technology for low-cost point-of-care diagnostics. This innovation enables precise quantification of small molecules and proteins in bodily fluids for personalized medicine.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Molecular Diagnostics
Background:
- Personalized therapies require patient-specific molecular data from bodily fluids.
- Point-of-care (POC) diagnostic devices offer potential for widespread patient benefit.
- Current POC technologies often rely on similar core platforms, limiting innovation.
Purpose of the Study:
- To present a new modular bioluminescent sensor technology for POC diagnostics.
- To enable quantification of small molecules and proteins at the point-of-care.
- To facilitate the development of low-cost diagnostic devices.
Main Methods:
- Development of highly modular bioluminescent sensors.
- Application of sensors for quantifying small molecules and proteins.
- Integration into low-cost POC diagnostic devices.
Main Results:
- Demonstration of a novel bioluminescent sensor platform.
- Capability to quantify small molecules and proteins at the POC.
- Potential for cost-effective diagnostic solutions.
Conclusions:
- The developed modular bioluminescent sensors represent an enabling technology for POC diagnostics.
- This approach addresses the need for diverse and low-cost analytical tools.
- It supports the advancement of personalized medicine through accessible molecular quantification.
