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Updated: Mar 5, 2026

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
Published on: September 14, 2019
Pathogenic Mechanisms of Cryptosporidium and Giardia
Gabriela Certad1, Eric Viscogliosi2, Magali Chabé2
1University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL, Center for Infection and Immunity of Lille, Lille, France; Medical Research Department, Hospital Group of the Catholic Institute of Lille, Faculty of Medicine and Maieutics, Catholic University of Lille, Lille, France.
Abstract:
Intestinal protozoa are important etiological agents of diarrhea, particularly in children, yet the public health risk they pose is often neglected. Results from the Global Enteric Multicenter Study (GEMS) showed that Cryptosporidium is among the leading causes of moderate to severe diarrhea in children under 2 years. Likewise, Giardia infects approximately 200 million individuals worldwide, and causes acute diarrhea in children under 5 years. Despite this recognized role as pathogens, the question is why and how these parasites cause disease in some individuals but not in others. This review focuses on known pathogenic mechanisms of Cryptosporidium and Giardia, and infection progress towards disease.
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